• 李闖創課題組完成高難度明星分子Vinigrol的最短全合成 近日,我?;瘜W系教授李闖創課題組在國際頂尖化學期刊《美國化學會志》(Journal of the American Chemical Society,簡稱JACS)發表論文,報道了明星天然產物Vinigrol的高效不對稱全合成。
    權澤衛課題組在《先進材料》發表重要研究進展 近日,南科大化學系教授權澤衛課題組在新型納米金屬間化合物領域取得最新進展,該成果發表在材料領域頂級期刊《先進材料》(Advanced Materials,IF:25.806)。
    化學系徐晶課題組在《美國化學會志》發表成重要進展 近日,徐晶課題組再次在復雜籠狀天然產物全合成領域取得重要進展,在《美國化學會志》發表重要研究論文,報道復雜籠狀虎皮楠生物堿Caldaphnidine O的國際首次全合成。
    化學系徐晶課題組在《美國化學會志》發表成果 近日,我?;瘜W系副教授徐晶課題組成功地完成了復雜虎皮楠生物堿Dapholdhamine B及其內酯衍生物的對映選擇性全合成工作,相關研究成果在《美國化學會志》(J. Am. Chem. Soc.)上發表。
    化學系劉心元課題組在自由基不對稱化學領域取得重要研究進展 近日,我?;瘜W系教授劉心元課題組在不對稱碳–碳鍵偶聯領域取得了重要研究進展。研究成果近期在《自然化學》(Nature Chemistry,IF:23.193)在線發表。
    化學系黃文忠課題組在《美國化學會志》發表最新研究成果 近日,我?;瘜W系副教授黃文忠課題組成功合成了一系列高發光強度的銠(III)配合物,并首次將其應用于有機電致發光二極管,取得重要研究進展。該成果在國際頂尖化學期刊《美國化學會志》
    【畢業季故事匯】 胡啟錕:人稱“胡博士”的科研達人
    【畢業季故事匯】 尚琳瑛:化學女孩從南科大通往劍橋的逐夢之路

    譚斌

    副系主任、教授

    化學系

    0755-88018315

    tanb@sustech.edu.cn

    研究方向
    不對稱軸手性化學、催化不對稱合成

    譚斌是南方科技大學終身教授,化學系副主任、博士生導師。2001年本科畢業于湖南科技大學。2005年碩士畢業于廈門大學化學系。 2010年博士畢業于新加坡南洋理工大學化學與生物化學系,導師鐘國富教授,研究方向為新型手性有機催化劑的設計及不對稱多米諾反應的研究。2010年3月至2012 年9月的博士后期間,在有機小分子催化領域的發源地--美國斯克普斯研究所 (The Scripps Research Institute)師從Barbas教授,繼續從事催化不對稱合成的研究。2012年9月,以準聘(Tenure-Track)副教授身份加入南方科技大學化學系。2018年1月晉升為終身正教授。


    到目前為止,在軸手性化學、不對稱多組分反應、自由基化學以及協同催化領域發表高水平研究論文60多篇,其中包括以第一作者或通訊作者身份發表的1篇Science、2篇Nature Chemistry、3篇Nature Communications、 6篇J. Am. Chem. Soc.、11篇Angew. Chem. Int. Ed. 和1篇Accounts of Chemical Research,論文總被引超過4000次。多篇論文被多篇文章被不同國際雜志重點評述或被選為封面文章。此外還有多篇高水平研究論文正在審稿和準備之中。

    目前擔任《中國科學-化學》和《中國化學》青年編委。








    2017年,2017中國新銳科技人物(知社學術圈)

    2017年,Asian Core Program Lectureship Award (日本)

    2016年,南方科技大學杰出科研獎

    2016年,Asian Core Program Lectureship Award (新加坡)


    ◆ 軸手性化學:不對稱催化與應用

    ◆ 有機催化不對稱多組分反應的研究 

    ◆ 手性藥物、手性材料的合成

    1、國家自然科學基金委面上項目(64萬)

    軸手性苯乙烯衍生物的不對稱合成與應用

     

    2、手性螺環二酚的關鍵技術研發及其應用(80萬)


     

    3、深圳市科創委基礎研究學科布局(300萬)

    含聯芳抗菌藥物關鍵問題研究

     

    4、國家自然科學基金委面上項目(65萬)

    有機催化不對稱合成聯芳基軸手性化合物

     

    5、深圳市科創委基礎研究自由探索(30)

    基于重氮吲哚酮的催化不對稱合成及其產物的抗癌活性研究

     

    6、國家自然科學基金委青年基金項目(25萬)

    不對稱合成具有重要生物活性3,3′-四氫吡咯螺羥吲哚骨架結構

     

    7、深圳市科創委基礎研究自由探索(10萬)

    四氫吡咯螺羥吲哚衍生物的設計和催化不對稱合成以及抗癌活性的研究

     

    8、核心骨架結構導向的催化不對稱合成(500+100萬)


     

    9、重大藥物的綠色制備(200萬)



    代表性研究成果(2013年8月至今):


    1.  Jian Zhang#, Peiyuan Yu#, Shao-Yu Li, He Sun, Shao-Hua Xiang,Jun (Joelle) Wang, Kendall N. Houk*, Bin Tan*. Asymmetric Phosphoric Acid-catalyzed Four-Component Ugi Reaction. Science 2018, 361, eaas8708. ( #equal contribution)


    2.  Yong-Bin Wang, Bin Tan*. Construction of Axially Chiral Compounds via Asymmetric Organocatalysis. Acc. Chem. Res. 2018, 51, 534.


    3.  Liang-Wen Qi#, Jian-Hui Mao#, Jian Zhang, Bin Tan*. Organocatalytic Asymmetric Arylation of Indoles Enabled by Azo Groups. Nat. Chem. 2018, 10, 58. ( #equal contribution)


    4.  Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu, Bin Tan*. Br?nsted Acid-Catalysed Enantioselective Construction of Axially Chiral Arylquinazolinones. Nat. Commun. 2017, 8, 15489.


    5.  Sheng-Cai Zheng, San Wu, Yun-Hao Zhang, Liu Ye, Bin Tan*. Organocatalytic Atroposelective Synthesis of Axially Chiral Styrenes. Nat. Commun. 2017, 8, 15238.


    6.  Lei Zhang, Jian Zhang, Ji Ma, Dao-Juan Cheng, Bin Tan*. Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal-Knorr Reaction. J. Am. Chem. Soc. 2017, 139, 1714.


    7.  Ye-Hui Chen, Liang-Wen Qi, Fang Fang, Bin Tan.* Organocatalytic Atroposelective Arylation of 2-Naphthylamines as a Practical Approach to Axially Chiral Biaryl Amino Alcohols. Angew. Chem. Int. Ed. 2017, 56, 16308.


    8.  Shaoyu Li, Ji-Wei Zhang, Xian-Lin Li, Bin Tan*. Phosphoric Acid-Catalyzed Asymmetric Synthesis of SPINOL Derivatives. J. Am. Chem. Soc. 2016, 138, 16561.


    9.  Jin-Hui Xu, Sheng-Cai. Zheng, Ji-Wei Zhang, Xin-Yuan Liu, Bin Tan*. Construction of Tropane Derivatives by Organocatalytic Asymmetric Dearomatization of Isoquinolines. Angew. Chem. Int. Ed. 2016, 55, 11834.


    10.Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu*, Bin Tan*. Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction. Nat. Commun. 2016, 7, 10677.


    11.Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu*, Bin Tan*. Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2?Naphthols. J. Am. Chem. Soc. 2015, 137, 15062.


    12.Jian Zhang#, Shao-Xia Lin#, Dao-Juan Cheng, Xin-Yuan Liu*,  Bin Tan*. Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. J. Am. Chem. Soc. 2015, 137, 14039. ( # equal contribution)


    13.Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan*. Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Angew. Chem. Int. Ed. 2015, 54, 9409.


    14.Zhi-Jia Fang#, Sheng-Cai Zheng#, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*. Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, 9528. ( #equal contribution)


    15.Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan*, Xin-Yuan Liu*. Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of  Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.


    16.Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan*, Xin-Yuan Liu*. Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkenes: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.


    17.Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene. Angew. Chem. Int. Ed. 2014, 53, 11890.


    18.Dao-Juan Cheng, Liang Yan, Shi-Kai Tian*, Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu*, Bin Tan*. Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Br?nsted Acid. Angew. Chem. Int. Ed. 2014, 53, 3684.


    19.Lin Huang, Jin-Shun Lin, Bin Tan*, Xin-Yuan Liu*. Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.


    20.Lin Huang, Sheng-Cai Zheng, Bin Tan*, Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589.


    21.Lin Huang, Sheng-Cai Zheng, Bin Tan*, Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon-Heteroatom/Carbon Bonds. Chem. Eur. J. 2015, 21, 6718.


    22.Lei Li, Jing-Yao Guo, Xing-Guo Liu, Su Chen, Yong Wang, Bin Tan*, Xin-Yuan Liu*. Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation. Org. Lett. 2014, 16, 6032.


    23.Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan*, Xin-Yuan Liu*. Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles. J. Org. Chem. 2014, 79, 7084.


    24.Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu*, Bin Tan*. In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles. Org. Lett. 2014, 16, 2192.


    25.Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement. Org. Lett. 2014, 16, 1000.


    26.Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan*, Xin-Yuan Liu*. Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles. Org. Lett. 2014, 16, 504.


    27.Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles. Chem. Eur. J. 2014, 20, 1332.


    28.Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan*, Carlos F. Barbas, III*. Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies. ACS Catal. 2014, 4, 743.


    代表性研究成果(獨立工作以前):


    1.  Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538.


    2.  Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rationally Designed Amide Donors for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381.


    3.  Tan, B.; Candeias, N.; Barbas III, C. F. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nat. Chem. 2011, 3, 473.


    4.  Tan B.; Hernández-Torres, G.; Barbas III, C. F. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. J. Am. Chem. Soc. 2011, 133, 12354.


    5.  Tan, B.; Candeias, N.; Barbas III, C. F. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J. Am. Chem. Soc. 2011, 133, 4672.


    6.  Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758.







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